35+ min ago   (72+ words) Hypoxia-inducible factor 1 alpha, or HIF1α, has long been celebrated as the master switch that allows cells to sense and survive low-oxygen conditions, a discovery that earned the 2019 Nobel Prize in Physiology or Medicine. In the intestine, this transcription factor is far…...

44+ min ago   (55+ words) Hepatocellular carcinoma, the most common form of primary liver cancer, remains one of the world’s most lethal malignancies, and its treatment options have changed surprisingly little over the past two decades. Now, a review published in Medical Oncology argues that…...

47+ min ago   (97+ words) A root long used in traditional East Asian medicine is now giving up its chemical secrets to modern analytical science. Researchers at Kyungpook National University, working with a collaborator at the University of California, Davis, have carried out an integrated…...

59+ min ago   (661+ words) A single protein called BAX sits at the gateway between life and death for human cells. When tissues are injured, stressed, or deprived of oxygen, BAX springs into action, punching holes in the outer membrane of mitochondria and triggering the…...

59+ min ago   (69+ words) Small-cell lung cancer has long been one of oncology’s most punishing adversaries. It grows with astonishing speed, spreads early, and presents a treatment paradox that has frustrated clinicians for decades: at diagnosis, tumors melt away under platinum-based chemotherapy, yet relapse…...

1+ hour, 6+ min ago   (611+ words) One of the most detailed long-term portraits of children’s aerobic fitness ever assembled suggests a troubling pattern in the final years of primary school. Researchers tracking hundreds of Norwegian children from first through sixth grade found that peak oxygen uptake,…...

1+ hour, 11+ min ago   (485+ words) A sprawling review of the meadow rue genus, Thalictrum, has catalogued a striking trove of biologically active plant chemicals across Africa and Asia, while simultaneously exposing how little of the evidence stands up to rigorous scientific scrutiny....

1+ hour, 12+ min ago   (682+ words) A study that promised a new way to deliver the asthma drug salbutamol sulphate through gelatin-based swellable hydrogels has been struck from the scientific record....

1+ hour, 17+ min ago   (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...

1+ hour, 21+ min ago   (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...